High-quality Antibody prediction at scale

Streamline antibody property predictions to accelerate biotherapeutic discovery

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3dpredict/Ab is a Software-as-a-Service (SaaS) platform designed to scale up best of breed antibody structure and property predictions with ease of use in mind.
Screen tens of thousands of antibody candidates for putative liabilities and developability issues.
Leveraging 3D structural information, efficient conformational sampling and pH titration, 3dpredict/Ab computes critical properties enabling users to prioritize sequences and train in-house machine learning model on high quality data.
References:
Raybould MIJ, Marks C, Krawczyk K, et al. Five computational developability guidelines for therapeutic antibody profiling. Proc Natl Acad Sci U S A. 2019;116(10):4025-4030. doi:10.1073/pnas.1810576116
Thorsteinson N, Gunn JR, Kelly K, Long W, Labute P. Structure-based charge calculations for predicting isoelectric point, viscosity, clearance, and profiling antibody therapeutics. MAbs. 2021;13(1):1981805. doi:10.1080/19420862.2021.1981805
Generate more accurate predictions for reducing developability issues and risk without any IT hassle. Conformational sampling allows you to produce less spurious results than before and you don't have to worry about whether your model conformation is representative enough.
Paste your sequences and structures (Excel, fasta, pdb, cif, AlphaFold) and retrieve high quality properties in a few minutes.

Prioritize which antibody to design next thanks to the advanced 3dpredict/Ab capabilities:

Easy to use web front-end
API for straightforward in-house integration
Supported formats:
- Fv, scFv, VHH, Fabs, bispecifics, and custom structures
Scaling for large datasets:
- Up to 30k Fv ensemble calculations/day
Easy authentication through SSO
Processes client data safely and securely on the cloud (ISO27001)

Discover 3dpredict/Ab

Users can simply upload FASTA files or Excel spreadsheets, and specify prediction parameters such as pH range, salt concentration, as well as the desired number of conformers expected for each pH calculation.

Utilizing Chemical Computing Group’s Molecular Operating Environment (MOE) technology for structure prediction and ensemble property calculations, 3dpredict delivers results obtained from multiple predictions, ensuring high quality results.