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Enhancing Life Science Research
 
 

Antibody prediction at scale​

Streamline antibody property prediction to accelerate biotherapeutic discovery

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  • 3dpredict is a Software-as-a-Service (SaaS) platform designed to scale up antibody structure and property prediction with easy-to-use technology developed by scientific and IT experts.

  • The solution allows scientists to prescreen and evaluate thousands of antibody candidates for putative liabilities and developability issues. By leveraging 3D structure information, 3dpredict computes critical properties, enabling users to filter and rank sequences effectively to quickly identify promising candidates.

    References:

    Raybould MIJ, Marks C, Krawczyk K, et al. Five computational developability guidelines for therapeutic antibody profiling. Proc Natl Acad Sci U S A. 2019;116(10):4025-4030. doi:10.1073/pnas.1810576116

    Thorsteinson N, Gunn JR, Kelly K, Long W, Labute P. Structure-based charge calculations for predicting isoelectric point, viscosity, clearance, and profiling antibody therapeutics. MAbs. 2021;13(1):1981805. doi:10.1080/19420862.2021.1981805

  • With its user-friendly interface and cloud hosting, 3dpredict streamlines predictions and accelerates antibody therapeutic discoveries. Its API integrates easily with existing research applications maximizing the advantages of your entire IT eco-system.

 

Successfully prioritize which antibody to design next thanks to the advanced 3dpredict capabilities:

  • Easily accessible system via a web front-end or a REST API

  • Supports various antibody formats, including Fab, scFv, nanobodies, and bispecific antibodies

  • Integrates seamlessly with the existing in-house IT ecosystem through the REST API

  • Capable of handling large datasets

    • Fv/Fab: 80k static pH calculations / day

    • Ig: 15k static pH calculations / day

  • Processes client data safely and securely on the cloud (ISO27001)

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Discover 3dpredict

Users can simply upload FASTA files or Excel spreadsheets, and specify prediction parameters such as pH range, salt concentration, as well as the desired number of conformers expected for each pH calculation.

Utilizing Chemical Computing Group’s Molecular Operating Environment (MOE) technology for structure prediction and ensemble property calculations,  3dpredict delivers results obtained from multiple predictions, ensuring high quality results. 

Antibody structure and properties prediction at scale - Join the early adopter programe

As an early adopter, you get exclusive access to our platform and it’s features, and an opportunity to provide valuable insights and feedback that will help shape the future development of 3dpredict.